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KOMP Repository (Knockout Mouse Project) KOMP Knock Out Knockout Mouse Mice
GO Terms found for Trem2
triggering receptor expressed on myeloid cells 2:

Biological Process GO:0001774 microglial cell activation
Biological Process GO:0001934 positive regulation of protein phosphorylation
Biological Process GO:0002282 microglial cell activation involved in immune response
Biological Process GO:0002588 positive regulation of antigen processing and presentation of peptide antigen via MHC class II
Biological Process GO:0002931 response to ischemia
Biological Process GO:0006911 phagocytosis, engulfment
Biological Process GO:0010468 regulation of gene expression
Biological Process GO:0010507 negative regulation of autophagy
Biological Process GO:0010628 positive regulation of gene expression
Biological Process GO:0010822 positive regulation of mitochondrion organization
Biological Process GO:0030316 osteoclast differentiation
Biological Process GO:0031663 lipopolysaccharide-mediated signaling pathway
Biological Process GO:0032006 regulation of TOR signaling
Biological Process GO:0032008 positive regulation of TOR signaling
Biological Process GO:0032497 detection of lipopolysaccharide
Biological Process GO:0032499 detection of peptidoglycan
Biological Process GO:0032675 regulation of interleukin-6 production
Biological Process GO:0032691 negative regulation of interleukin-1 beta production
Biological Process GO:0032720 negative regulation of tumor necrosis factor production
Biological Process GO:0032733 positive regulation of interleukin-10 production
Biological Process GO:0034241 positive regulation of macrophage fusion
Biological Process GO:0042742 defense response to bacterium
Biological Process GO:0043066 negative regulation of apoptotic process
Biological Process GO:0043277 apoptotic cell clearance
Biological Process GO:0045087 innate immune response
Biological Process GO:0045088 regulation of innate immune response
Biological Process GO:0045672 positive regulation of osteoclast differentiation
Biological Process GO:0048143 astrocyte activation
Biological Process GO:0050714 positive regulation of protein secretion
Biological Process GO:0050730 regulation of peptidyl-tyrosine phosphorylation
Biological Process GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
Biological Process GO:0050850 positive regulation of calcium-mediated signaling
Biological Process GO:0050921 positive regulation of chemotaxis
Biological Process GO:0060075 regulation of resting membrane potential
Biological Process GO:0060100 positive regulation of phagocytosis, engulfment
Biological Process GO:0061518 microglial cell proliferation
Biological Process GO:0070374 positive regulation of ERK1 and ERK2 cascade
Biological Process GO:0070392 detection of lipoteichoic acid
Biological Process GO:0071223 cellular response to lipoteichoic acid
Biological Process GO:0071224 cellular response to peptidoglycan
Biological Process GO:0071640 regulation of macrophage inflammatory protein 1 alpha production
Biological Process GO:0097028 dendritic cell differentiation
Biological Process GO:0097242 amyloid-beta clearance
Biological Process GO:0098657 import into cell
Biological Process GO:0120035 regulation of plasma membrane bounded cell projection organization
Biological Process GO:0150062 complement-mediated synapse pruning
Biological Process GO:0150076 neuroinflammatory response
Biological Process GO:0150078 positive regulation of neuroinflammatory response
Biological Process GO:1900223 positive regulation of amyloid-beta clearance
Biological Process GO:1901076 positive regulation of engulfment of apoptotic cell
Biological Process GO:1901224 positive regulation of NIK/NF-kappaB signaling
Biological Process GO:1901800 positive regulation of proteasomal protein catabolic process
Biological Process GO:1901980 positive regulation of inward rectifier potassium channel activity
Biological Process GO:1902531 regulation of intracellular signal transduction
Biological Process GO:1903078 positive regulation of protein localization to plasma membrane
Biological Process GO:1903082 positive regulation of C-C chemokine receptor CCR7 signaling pathway
Biological Process GO:1903980 positive regulation of microglial cell activation
Biological Process GO:1904093 negative regulation of autophagic cell death
Biological Process GO:1904141 positive regulation of microglial cell migration
Biological Process GO:1904646 cellular response to amyloid-beta
Biological Process GO:1905291 positive regulation of CAMKK-AMPK signaling cascade
Biological Process GO:2000350 positive regulation of CD40 signaling pathway
Biological Process GO:2001171 positive regulation of ATP biosynthetic process
Cellular Component GO:0005576 extracellular region
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0005887 integral component of plasma membrane
Cellular Component GO:0016020 membrane
Cellular Component GO:0016021 integral component of membrane
Cellular Component GO:0031226 intrinsic component of plasma membrane
Molecular Function GO:0001530 lipopolysaccharide binding
Molecular Function GO:0001540 amyloid-beta binding
Molecular Function GO:0004888 transmembrane signaling receptor activity
Molecular Function GO:0005515 protein binding
Molecular Function GO:0005543 phospholipid binding
Molecular Function GO:0008035 high-density lipoprotein particle binding
Molecular Function GO:0008289 lipid binding
Molecular Function GO:0030169 low-density lipoprotein particle binding
Molecular Function GO:0034185 apolipoprotein binding
Molecular Function GO:0034186 apolipoprotein A-I binding
Molecular Function GO:0034189 very-low-density lipoprotein particle binding
Molecular Function GO:0038023 signaling receptor activity
Molecular Function GO:0042834 peptidoglycan binding
Molecular Function GO:0044877 protein-containing complex binding
Molecular Function GO:0070891 lipoteichoic acid binding
Molecular Function GO:0071813 lipoprotein particle binding
Molecular Function GO:0097110 scaffold protein binding
Molecular Function GO:1990782 protein tyrosine kinase binding

Gene - GO associations are updated daily from MGI

The KOMP Repository Collection is located at the MMRRC at the University of California, Davis and Children’s Hospital Oakland Research Institute. Question? Comments? For Mice, Cells, and germplasm please contact us at mmrrc@ucdavis.edu, US 1-888-KOMP-MICE or International +1-530-752-KOMP, or for vectors komporders@chori.org or +1-510-450-7917.