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KOMP Repository (Knockout Mouse Project) KOMP Knock Out Knockout Mouse Mice
GO Terms found for Smad4
SMAD family member 4:

Biological Process GO:0000122 negative regulation of transcription from RNA polymerase II promoter
Biological Process GO:0001541 ovarian follicle development
Biological Process GO:0001649 osteoblast differentiation
Biological Process GO:0001658 branching involved in ureteric bud morphogenesis
Biological Process GO:0001666 response to hypoxia
Biological Process GO:0001701 in utero embryonic development
Biological Process GO:0001702 gastrulation with mouth forming second
Biological Process GO:0001822 kidney development
Biological Process GO:0003148 outflow tract septum morphogenesis
Biological Process GO:0003190 atrioventricular valve formation
Biological Process GO:0003198 epithelial to mesenchymal transition involved in endocardial cushion formation
Biological Process GO:0003220 left ventricular cardiac muscle tissue morphogenesis
Biological Process GO:0003251 positive regulation of cell proliferation involved in heart valve morphogenesis
Biological Process GO:0003279 cardiac septum development
Biological Process GO:0003360 brainstem development
Biological Process GO:0006351 transcription, DNA-templated
Biological Process GO:0006355 regulation of transcription, DNA-templated
Biological Process GO:0006357 regulation of transcription from RNA polymerase II promoter
Biological Process GO:0006879 cellular iron ion homeostasis
Biological Process GO:0007179 transforming growth factor beta receptor signaling pathway
Biological Process GO:0007183 SMAD protein complex assembly
Biological Process GO:0007283 spermatogenesis
Biological Process GO:0007338 single fertilization
Biological Process GO:0007369 gastrulation
Biological Process GO:0007411 axon guidance
Biological Process GO:0007492 endoderm development
Biological Process GO:0007498 mesoderm development
Biological Process GO:0008283 cell proliferation
Biological Process GO:0008285 negative regulation of cell proliferation
Biological Process GO:0008584 male gonad development
Biological Process GO:0008585 female gonad development
Biological Process GO:0009952 anterior/posterior pattern specification
Biological Process GO:0010614 negative regulation of cardiac muscle hypertrophy
Biological Process GO:0010666 positive regulation of cardiac muscle cell apoptotic process
Biological Process GO:0010718 positive regulation of epithelial to mesenchymal transition
Biological Process GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation
Biological Process GO:0014033 neural crest cell differentiation
Biological Process GO:0017015 regulation of transforming growth factor beta receptor signaling pathway
Biological Process GO:0030308 negative regulation of cell growth
Biological Process GO:0030509 BMP signaling pathway
Biological Process GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway
Biological Process GO:0030513 positive regulation of BMP signaling pathway
Biological Process GO:0032525 somite rostral/caudal axis specification
Biological Process GO:0032909 regulation of transforming growth factor beta2 production
Biological Process GO:0033686 positive regulation of luteinizing hormone secretion
Biological Process GO:0035556 intracellular signal transduction
Biological Process GO:0036302 atrioventricular canal development
Biological Process GO:0042060 wound healing
Biological Process GO:0042118 endothelial cell activation
Biological Process GO:0042127 regulation of cell proliferation
Biological Process GO:0042177 negative regulation of protein catabolic process
Biological Process GO:0042733 embryonic digit morphogenesis
Biological Process GO:0045892 negative regulation of transcription, DNA-templated
Biological Process GO:0045893 positive regulation of transcription, DNA-templated
Biological Process GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Biological Process GO:0046881 positive regulation of follicle-stimulating hormone secretion
Biological Process GO:0048589 developmental growth
Biological Process GO:0048663 neuron fate commitment
Biological Process GO:0048729 tissue morphogenesis
Biological Process GO:0048733 sebaceous gland development
Biological Process GO:0048859 formation of anatomical boundary
Biological Process GO:0051098 regulation of binding
Biological Process GO:0051571 positive regulation of histone H3-K4 methylation
Biological Process GO:0051797 regulation of hair follicle development
Biological Process GO:0060021 palate development
Biological Process GO:0060065 uterus development
Biological Process GO:0060391 positive regulation of SMAD protein import into nucleus
Biological Process GO:0060395 SMAD protein signal transduction
Biological Process GO:0060412 ventricular septum morphogenesis
Biological Process GO:0060548 negative regulation of cell death
Biological Process GO:0060956 endocardial cell differentiation
Biological Process GO:0061040 female gonad morphogenesis
Biological Process GO:0070102 interleukin-6-mediated signaling pathway
Biological Process GO:0070207 protein homotrimerization
Biological Process GO:0070371 ERK1 and ERK2 cascade
Biological Process GO:0070373 negative regulation of ERK1 and ERK2 cascade
Biological Process GO:0071333 cellular response to glucose stimulus
Biological Process GO:0071559 response to transforming growth factor beta
Biological Process GO:0072133 metanephric mesenchyme morphogenesis
Biological Process GO:0072134 nephrogenic mesenchyme morphogenesis
Biological Process GO:0072520 seminiferous tubule development
Biological Process GO:1905305 negative regulation of cardiac myofibril assembly
Biological Process GO:2000617 positive regulation of histone H3-K9 acetylation
Cellular Component GO:0000790 nuclear chromatin
Cellular Component GO:0005622 intracellular
Cellular Component GO:0005634 nucleus
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005667 transcription factor complex
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005813 centrosome
Cellular Component GO:0005829 cytosol
Cellular Component GO:0032444 activin responsive factor complex
Cellular Component GO:0043234 protein complex
Cellular Component GO:0071141 SMAD protein complex
Cellular Component GO:0090575 RNA polymerase II transcription factor complex
Molecular Function GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
Molecular Function GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
Molecular Function GO:0000987 core promoter proximal region sequence-specific DNA binding
Molecular Function GO:0000988 transcription factor activity, protein binding
Molecular Function GO:0001076 transcription factor activity, RNA polymerase II transcription factor binding
Molecular Function GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
Molecular Function GO:0001085 RNA polymerase II transcription factor binding
Molecular Function GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0003682 chromatin binding
Molecular Function GO:0003700 transcription factor activity, sequence-specific DNA binding
Molecular Function GO:0005515 protein binding
Molecular Function GO:0005518 collagen binding
Molecular Function GO:0030616 transforming growth factor beta receptor, common-partner cytoplasmic mediator activity
Molecular Function GO:0031005 filamin binding
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0042803 protein homodimerization activity
Molecular Function GO:0043199 sulfate binding
Molecular Function GO:0043565 sequence-specific DNA binding
Molecular Function GO:0044212 transcription regulatory region DNA binding
Molecular Function GO:0046332 SMAD binding
Molecular Function GO:0046872 metal ion binding
Molecular Function GO:0046982 protein heterodimerization activity
Molecular Function GO:0070411 I-SMAD binding
Molecular Function GO:0070412 R-SMAD binding

Gene - GO associations are updated daily from MGI


The KOMP Repository is located at the University of California Davis and Children’s Hospital Oakland Research Institute. Question? Comments? For Mice, Cells, and germplasm please contact us at service@komp.org, US 1-888-KOMP-MICE or International +1-530-752-KOMP, or for vectors komporders@chori.org or +1-510-450-7917.