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KOMP Repository (Knockout Mouse Project) KOMP Knock Out Knockout Mouse Mice
GO Terms found for Gclc
glutamate-cysteine ligase, catalytic subunit:

Biological Process GO:0006534 cysteine metabolic process
Biological Process GO:0006536 glutamate metabolic process
Biological Process GO:0006749 glutathione metabolic process
Biological Process GO:0006750 glutathione biosynthetic process
Biological Process GO:0006979 response to oxidative stress
Biological Process GO:0009408 response to heat
Biological Process GO:0009410 response to xenobiotic stimulus
Biological Process GO:0009725 response to hormone
Biological Process GO:0019852 L-ascorbic acid metabolic process
Biological Process GO:0031397 negative regulation of protein ubiquitination
Biological Process GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
Biological Process GO:0043066 negative regulation of apoptotic process
Biological Process GO:0043524 negative regulation of neuron apoptotic process
Biological Process GO:0045454 cell redox homeostasis
Biological Process GO:0045892 negative regulation of transcription, DNA-templated
Biological Process GO:0046685 response to arsenic-containing substance
Biological Process GO:0051409 response to nitrosative stress
Biological Process GO:0051900 regulation of mitochondrial depolarization
Biological Process GO:0097746 regulation of blood vessel diameter
Biological Process GO:1901029 negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
Biological Process GO:2000490 negative regulation of hepatic stellate cell activation
Biological Process GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
Cellular Component GO:0005829 cytosol
Cellular Component GO:0017109 glutamate-cysteine ligase complex
Molecular Function GO:0000166 nucleotide binding
Molecular Function GO:0000287 magnesium ion binding
Molecular Function GO:0003824 catalytic activity
Molecular Function GO:0004357 glutamate-cysteine ligase activity
Molecular Function GO:0005515 protein binding
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0016595 glutamate binding
Molecular Function GO:0016874 ligase activity
Molecular Function GO:0043531 ADP binding
Molecular Function GO:0044877 protein-containing complex binding
Molecular Function GO:0050662 coenzyme binding

Gene - GO associations are updated daily from MGI

The KOMP Repository Collection is located at the MMRRC at the University of California, Davis and Children’s Hospital Oakland Research Institute. Question? Comments? For Mice, Cells, and germplasm please contact us at mmrrc@ucdavis.edu, US 1-888-KOMP-MICE or International +1-530-752-KOMP, or for vectors komporders@chori.org or +1-510-450-7917.