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KOMP Repository (Knockout Mouse Project) KOMP Knock Out Knockout Mouse Mice
GO Terms found for App
amyloid beta (A4) precursor protein:

Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0000185 activation of MAPKKK activity
Biological Process GO:0000187 activation of MAPK activity
Biological Process GO:0001774 microglial cell activation
Biological Process GO:0001878 response to yeast
Biological Process GO:0001934 positive regulation of protein phosphorylation
Biological Process GO:0001967 suckling behavior
Biological Process GO:0002265 astrocyte activation involved in immune response
Biological Process GO:0006357 regulation of transcription by RNA polymerase II
Biological Process GO:0006378 mRNA polyadenylation
Biological Process GO:0006417 regulation of translation
Biological Process GO:0006468 protein phosphorylation
Biological Process GO:0006878 cellular copper ion homeostasis
Biological Process GO:0006897 endocytosis
Biological Process GO:0006915 apoptotic process
Biological Process GO:0006979 response to oxidative stress
Biological Process GO:0007155 cell adhesion
Biological Process GO:0007176 regulation of epidermal growth factor-activated receptor activity
Biological Process GO:0007186 G protein-coupled receptor signaling pathway
Biological Process GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
Biological Process GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
Biological Process GO:0007219 Notch signaling pathway
Biological Process GO:0007399 nervous system development
Biological Process GO:0007409 axonogenesis
Biological Process GO:0007611 learning or memory
Biological Process GO:0007612 learning
Biological Process GO:0007613 memory
Biological Process GO:0007617 mating behavior
Biological Process GO:0007626 locomotory behavior
Biological Process GO:0008088 axo-dendritic transport
Biological Process GO:0008203 cholesterol metabolic process
Biological Process GO:0008285 negative regulation of cell population proliferation
Biological Process GO:0008306 associative learning
Biological Process GO:0008344 adult locomotory behavior
Biological Process GO:0008542 visual learning
Biological Process GO:0009987 cellular process
Biological Process GO:0010466 negative regulation of peptidase activity
Biological Process GO:0010468 regulation of gene expression
Biological Process GO:0010628 positive regulation of gene expression
Biological Process GO:0010629 negative regulation of gene expression
Biological Process GO:0010800 positive regulation of peptidyl-threonine phosphorylation
Biological Process GO:0010971 positive regulation of G2/M transition of mitotic cell cycle
Biological Process GO:0014005 microglia development
Biological Process GO:0016199 axon midline choice point recognition
Biological Process GO:0016322 neuron remodeling
Biological Process GO:0016358 dendrite development
Biological Process GO:0019722 calcium-mediated signaling
Biological Process GO:0019731 antibacterial humoral response
Biological Process GO:0019732 antifungal humoral response
Biological Process GO:0030198 extracellular matrix organization
Biological Process GO:0030900 forebrain development
Biological Process GO:0031175 neuron projection development
Biological Process GO:0032092 positive regulation of protein binding
Biological Process GO:0032640 tumor necrosis factor production
Biological Process GO:0032722 positive regulation of chemokine production
Biological Process GO:0032729 positive regulation of interferon-gamma production
Biological Process GO:0032731 positive regulation of interleukin-1 beta production
Biological Process GO:0032755 positive regulation of interleukin-6 production
Biological Process GO:0032760 positive regulation of tumor necrosis factor production
Biological Process GO:0032930 positive regulation of superoxide anion generation
Biological Process GO:0033138 positive regulation of peptidyl-serine phosphorylation
Biological Process GO:0034121 regulation of toll-like receptor signaling pathway
Biological Process GO:0035066 positive regulation of histone acetylation
Biological Process GO:0035235 ionotropic glutamate receptor signaling pathway
Biological Process GO:0040014 regulation of multicellular organism growth
Biological Process GO:0042327 positive regulation of phosphorylation
Biological Process GO:0043065 positive regulation of apoptotic process
Biological Process GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
Biological Process GO:0043393 regulation of protein binding
Biological Process GO:0043410 positive regulation of MAPK cascade
Biological Process GO:0043525 positive regulation of neuron apoptotic process
Biological Process GO:0045087 innate immune response
Biological Process GO:0045429 positive regulation of nitric oxide biosynthetic process
Biological Process GO:0045665 negative regulation of neuron differentiation
Biological Process GO:0045666 positive regulation of neuron differentiation
Biological Process GO:0045745 positive regulation of G protein-coupled receptor signaling pathway
Biological Process GO:0045821 positive regulation of glycolytic process
Biological Process GO:0045931 positive regulation of mitotic cell cycle
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0046330 positive regulation of JNK cascade
Biological Process GO:0048143 astrocyte activation
Biological Process GO:0048169 regulation of long-term neuronal synaptic plasticity
Biological Process GO:0048669 collateral sprouting in absence of injury
Biological Process GO:0050729 positive regulation of inflammatory response
Biological Process GO:0050730 regulation of peptidyl-tyrosine phosphorylation
Biological Process GO:0050803 regulation of synapse structure or activity
Biological Process GO:0050808 synapse organization
Biological Process GO:0050829 defense response to Gram-negative bacterium
Biological Process GO:0050830 defense response to Gram-positive bacterium
Biological Process GO:0050885 neuromuscular process controlling balance
Biological Process GO:0050890 cognition
Biological Process GO:0051044 positive regulation of membrane protein ectodomain proteolysis
Biological Process GO:0051091 positive regulation of DNA-binding transcription factor activity
Biological Process GO:0051092 positive regulation of NF-kappaB transcription factor activity
Biological Process GO:0051124 synaptic growth at neuromuscular junction
Biological Process GO:0051247 positive regulation of protein metabolic process
Biological Process GO:0051260 protein homooligomerization
Biological Process GO:0051262 protein tetramerization
Biological Process GO:0051402 neuron apoptotic process
Biological Process GO:0051563 smooth endoplasmic reticulum calcium ion homeostasis
Biological Process GO:0060291 long-term synaptic potentiation
Biological Process GO:0061098 positive regulation of protein tyrosine kinase activity
Biological Process GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide
Biological Process GO:0061903 positive regulation of 1-phosphatidylinositol-3-kinase activity
Biological Process GO:0070206 protein trimerization
Biological Process GO:0070374 positive regulation of ERK1 and ERK2 cascade
Biological Process GO:0070555 response to interleukin-1
Biological Process GO:0071874 cellular response to norepinephrine stimulus
Biological Process GO:0090026 positive regulation of monocyte chemotaxis
Biological Process GO:0090090 negative regulation of canonical Wnt signaling pathway
Biological Process GO:0090647 modulation of age-related behavioral decline
Biological Process GO:0098815 modulation of excitatory postsynaptic potential
Biological Process GO:0150003 regulation of spontaneous synaptic transmission
Biological Process GO:1900122 positive regulation of receptor binding
Biological Process GO:1900181 negative regulation of protein localization to nucleus
Biological Process GO:1900272 negative regulation of long-term synaptic potentiation
Biological Process GO:1900273 positive regulation of long-term synaptic potentiation
Biological Process GO:1901215 negative regulation of neuron death
Biological Process GO:1901216 positive regulation of neuron death
Biological Process GO:1901224 positive regulation of NIK/NF-kappaB signaling
Biological Process GO:1902004 positive regulation of amyloid-beta formation
Biological Process GO:1902894 negative regulation of pri-miRNA transcription by RNA polymerase II
Biological Process GO:1902949 positive regulation of tau-protein kinase activity
Biological Process GO:1902950 regulation of dendritic spine maintenance
Biological Process GO:1902961 positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
Biological Process GO:1903048 regulation of acetylcholine-gated cation channel activity
Biological Process GO:1903223 positive regulation of oxidative stress-induced neuron death
Biological Process GO:1903523 negative regulation of blood circulation
Biological Process GO:1904022 positive regulation of G protein-coupled receptor internalization
Biological Process GO:1904472 positive regulation of endothelin production
Biological Process GO:1904591 positive regulation of protein import
Biological Process GO:1904646 cellular response to amyloid-beta
Biological Process GO:1905606 regulation of presynapse assembly
Biological Process GO:1905893 positive regulation of cellular response to thapsigargin
Biological Process GO:1905896 positive regulation of cellular response to tunicamycin
Biological Process GO:1905898 positive regulation of response to endoplasmic reticulum stress
Biological Process GO:1905906 regulation of amyloid fibril formation
Biological Process GO:1905908 positive regulation of amyloid fibril formation
Biological Process GO:1905945 regulation of response to calcium ion
Biological Process GO:1990000 amyloid fibril formation
Biological Process GO:1990535 neuron projection maintenance
Biological Process GO:2000406 positive regulation of T cell migration
Biological Process GO:2000463 positive regulation of excitatory postsynaptic potential
Cellular Component GO:0005576 extracellular region
Cellular Component GO:0005615 extracellular space
Cellular Component GO:0005634 nucleus
Cellular Component GO:0005641 nuclear envelope lumen
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0005764 lysosome
Cellular Component GO:0005768 endosome
Cellular Component GO:0005769 early endosome
Cellular Component GO:0005791 rough endoplasmic reticulum
Cellular Component GO:0005794 Golgi apparatus
Cellular Component GO:0005798 Golgi-associated vesicle
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0005905 clathrin-coated pit
Cellular Component GO:0005911 cell-cell junction
Cellular Component GO:0008021 synaptic vesicle
Cellular Component GO:0009986 cell surface
Cellular Component GO:0016020 membrane
Cellular Component GO:0016021 integral component of membrane
Cellular Component GO:0030134 COPII-coated ER to Golgi transport vesicle
Cellular Component GO:0030424 axon
Cellular Component GO:0030426 growth cone
Cellular Component GO:0031410 cytoplasmic vesicle
Cellular Component GO:0031594 neuromuscular junction
Cellular Component GO:0032991 protein-containing complex
Cellular Component GO:0034361 very-low-density lipoprotein particle
Cellular Component GO:0034362 low-density lipoprotein particle
Cellular Component GO:0034363 intermediate-density lipoprotein particle
Cellular Component GO:0034364 high-density lipoprotein particle
Cellular Component GO:0035253 ciliary rootlet
Cellular Component GO:0042995 cell projection
Cellular Component GO:0043005 neuron projection
Cellular Component GO:0043235 receptor complex
Cellular Component GO:0044297 cell body
Cellular Component GO:0044304 main axon
Cellular Component GO:0045121 membrane raft
Cellular Component GO:0045177 apical part of cell
Cellular Component GO:0048471 perinuclear region of cytoplasm
Cellular Component GO:0048786 presynaptic active zone
Cellular Component GO:0051233 spindle midzone
Cellular Component GO:0055037 recycling endosome
Cellular Component GO:0070381 endosome to plasma membrane transport vesicle
Cellular Component GO:0097449 astrocyte projection
Cellular Component GO:0098793 presynapse
Cellular Component GO:0098794 postsynapse
Cellular Component GO:0106003 amyloid-beta complex
Cellular Component GO:1990761 growth cone lamellipodium
Cellular Component GO:1990777 lipoprotein particle
Cellular Component GO:1990812 growth cone filopodium
Molecular Function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
Molecular Function GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding
Molecular Function GO:0001664 G protein-coupled receptor binding
Molecular Function GO:0004867 serine-type endopeptidase inhibitor activity
Molecular Function GO:0005102 signaling receptor binding
Molecular Function GO:0005109 frizzled binding
Molecular Function GO:0005158 insulin receptor binding
Molecular Function GO:0005178 integrin binding
Molecular Function GO:0005515 protein binding
Molecular Function GO:0008201 heparin binding
Molecular Function GO:0016504 peptidase activator activity
Molecular Function GO:0019899 enzyme binding
Molecular Function GO:0030414 peptidase inhibitor activity
Molecular Function GO:0030546 signaling receptor activator activity
Molecular Function GO:0033130 acetylcholine receptor binding
Molecular Function GO:0034185 apolipoprotein binding
Molecular Function GO:0042056 chemoattractant activity
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0042803 protein homodimerization activity
Molecular Function GO:0043395 heparan sulfate proteoglycan binding
Molecular Function GO:0046872 metal ion binding
Molecular Function GO:0046875 ephrin receptor binding
Molecular Function GO:0046914 transition metal ion binding
Molecular Function GO:0046982 protein heterodimerization activity
Molecular Function GO:0046983 protein dimerization activity
Molecular Function GO:0050750 low-density lipoprotein particle receptor binding
Molecular Function GO:0050786 RAGE receptor binding
Molecular Function GO:0051087 chaperone binding
Molecular Function GO:0051425 PTB domain binding
Molecular Function GO:0070851 growth factor receptor binding

Gene - GO associations are updated daily from MGI

The KOMP Repository Collection is located at the MMRRC at the University of California Davis. Question? Comments? Please contact us at mmrrc@ucdavis.edu, US 1-888-566-7643 or International +1-530-754-6677.