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KOMP Repository (Knockout Mouse Project) KOMP Knock Out Knockout Mouse Mice
GO Terms found for App
amyloid beta (A4) precursor protein:

Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0000185 activation of MAPKKK activity
Biological Process GO:0000187 activation of MAPK activity
Biological Process GO:0001774 microglial cell activation
Biological Process GO:0001878 response to yeast
Biological Process GO:0001934 positive regulation of protein phosphorylation
Biological Process GO:0001967 suckling behavior
Biological Process GO:0002265 astrocyte activation involved in immune response
Biological Process GO:0006357 regulation of transcription by RNA polymerase II
Biological Process GO:0006378 mRNA polyadenylation
Biological Process GO:0006417 regulation of translation
Biological Process GO:0006468 protein phosphorylation
Biological Process GO:0006878 cellular copper ion homeostasis
Biological Process GO:0006897 endocytosis
Biological Process GO:0006915 apoptotic process
Biological Process GO:0006979 response to oxidative stress
Biological Process GO:0007155 cell adhesion
Biological Process GO:0007176 regulation of epidermal growth factor-activated receptor activity
Biological Process GO:0007186 G protein-coupled receptor signaling pathway
Biological Process GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
Biological Process GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
Biological Process GO:0007219 Notch signaling pathway
Biological Process GO:0007399 nervous system development
Biological Process GO:0007409 axonogenesis
Biological Process GO:0007611 learning or memory
Biological Process GO:0007612 learning
Biological Process GO:0007613 memory
Biological Process GO:0007617 mating behavior
Biological Process GO:0007626 locomotory behavior
Biological Process GO:0008088 axo-dendritic transport
Biological Process GO:0008203 cholesterol metabolic process
Biological Process GO:0008285 negative regulation of cell population proliferation
Biological Process GO:0008306 associative learning
Biological Process GO:0008344 adult locomotory behavior
Biological Process GO:0008542 visual learning
Biological Process GO:0009987 cellular process
Biological Process GO:0010466 negative regulation of peptidase activity
Biological Process GO:0010468 regulation of gene expression
Biological Process GO:0010628 positive regulation of gene expression
Biological Process GO:0010629 negative regulation of gene expression
Biological Process GO:0010800 positive regulation of peptidyl-threonine phosphorylation
Biological Process GO:0010971 positive regulation of G2/M transition of mitotic cell cycle
Biological Process GO:0014005 microglia development
Biological Process GO:0016199 axon midline choice point recognition
Biological Process GO:0016322 neuron remodeling
Biological Process GO:0016358 dendrite development
Biological Process GO:0019722 calcium-mediated signaling
Biological Process GO:0019731 antibacterial humoral response
Biological Process GO:0019732 antifungal humoral response
Biological Process GO:0030198 extracellular matrix organization
Biological Process GO:0030900 forebrain development
Biological Process GO:0031175 neuron projection development
Biological Process GO:0032092 positive regulation of protein binding
Biological Process GO:0032640 tumor necrosis factor production
Biological Process GO:0032930 positive regulation of superoxide anion generation
Biological Process GO:0033138 positive regulation of peptidyl-serine phosphorylation
Biological Process GO:0034121 regulation of toll-like receptor signaling pathway
Biological Process GO:0035066 positive regulation of histone acetylation
Biological Process GO:0035235 ionotropic glutamate receptor signaling pathway
Biological Process GO:0040014 regulation of multicellular organism growth
Biological Process GO:0042327 positive regulation of phosphorylation
Biological Process GO:0042535 positive regulation of tumor necrosis factor biosynthetic process
Biological Process GO:0043065 positive regulation of apoptotic process
Biological Process GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
Biological Process GO:0043393 regulation of protein binding
Biological Process GO:0043410 positive regulation of MAPK cascade
Biological Process GO:0043525 positive regulation of neuron apoptotic process
Biological Process GO:0045080 positive regulation of chemokine biosynthetic process
Biological Process GO:0045087 innate immune response
Biological Process GO:0045410 positive regulation of interleukin-6 biosynthetic process
Biological Process GO:0045429 positive regulation of nitric oxide biosynthetic process
Biological Process GO:0045665 negative regulation of neuron differentiation
Biological Process GO:0045666 positive regulation of neuron differentiation
Biological Process GO:0045745 positive regulation of G protein-coupled receptor signaling pathway
Biological Process GO:0045821 positive regulation of glycolytic process
Biological Process GO:0045931 positive regulation of mitotic cell cycle
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0046330 positive regulation of JNK cascade
Biological Process GO:0048143 astrocyte activation
Biological Process GO:0048169 regulation of long-term neuronal synaptic plasticity
Biological Process GO:0048669 collateral sprouting in absence of injury
Biological Process GO:0050725 positive regulation of interleukin-1 beta biosynthetic process
Biological Process GO:0050730 regulation of peptidyl-tyrosine phosphorylation
Biological Process GO:0050803 regulation of synapse structure or activity
Biological Process GO:0050808 synapse organization
Biological Process GO:0050829 defense response to Gram-negative bacterium
Biological Process GO:0050830 defense response to Gram-positive bacterium
Biological Process GO:0050885 neuromuscular process controlling balance
Biological Process GO:0050890 cognition
Biological Process GO:0051044 positive regulation of membrane protein ectodomain proteolysis
Biological Process GO:0051091 positive regulation of DNA-binding transcription factor activity
Biological Process GO:0051092 positive regulation of NF-kappaB transcription factor activity
Biological Process GO:0051124 synaptic growth at neuromuscular junction
Biological Process GO:0051247 positive regulation of protein metabolic process
Biological Process GO:0051260 protein homooligomerization
Biological Process GO:0051262 protein tetramerization
Biological Process GO:0051402 neuron apoptotic process
Biological Process GO:0051563 smooth endoplasmic reticulum calcium ion homeostasis
Biological Process GO:0060291 long-term synaptic potentiation
Biological Process GO:0061098 positive regulation of protein tyrosine kinase activity
Biological Process GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide
Biological Process GO:0061903 positive regulation of 1-phosphatidylinositol-3-kinase activity
Biological Process GO:0070206 protein trimerization
Biological Process GO:0070374 positive regulation of ERK1 and ERK2 cascade
Biological Process GO:0070555 response to interleukin-1
Biological Process GO:0071874 cellular response to norepinephrine stimulus
Biological Process GO:0090026 positive regulation of monocyte chemotaxis
Biological Process GO:0090090 negative regulation of canonical Wnt signaling pathway
Biological Process GO:0090647 modulation of age-related behavioral decline
Biological Process GO:0098815 modulation of excitatory postsynaptic potential
Biological Process GO:0150003 regulation of spontaneous synaptic transmission
Biological Process GO:1900122 positive regulation of receptor binding
Biological Process GO:1900181 negative regulation of protein localization to nucleus
Biological Process GO:1900272 negative regulation of long-term synaptic potentiation
Biological Process GO:1900273 positive regulation of long-term synaptic potentiation
Biological Process GO:1901215 negative regulation of neuron death
Biological Process GO:1901216 positive regulation of neuron death
Biological Process GO:1901224 positive regulation of NIK/NF-kappaB signaling
Biological Process GO:1902004 positive regulation of amyloid-beta formation
Biological Process GO:1902715 positive regulation of interferon-gamma secretion
Biological Process GO:1902894 negative regulation of pri-miRNA transcription by RNA polymerase II
Biological Process GO:1902949 positive regulation of tau-protein kinase activity
Biological Process GO:1902950 regulation of dendritic spine maintenance
Biological Process GO:1902961 positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
Biological Process GO:1903048 regulation of acetylcholine-gated cation channel activity
Biological Process GO:1903223 positive regulation of oxidative stress-induced neuron death
Biological Process GO:1903523 negative regulation of blood circulation
Biological Process GO:1904022 positive regulation of G protein-coupled receptor internalization
Biological Process GO:1904472 positive regulation of endothelin secretion
Biological Process GO:1904591 positive regulation of protein import
Biological Process GO:1904646 cellular response to amyloid-beta
Biological Process GO:1905606 regulation of presynapse assembly
Biological Process GO:1905893 positive regulation of cellular response to thapsigargin
Biological Process GO:1905896 positive regulation of cellular response to tunicamycin
Biological Process GO:1905898 positive regulation of response to endoplasmic reticulum stress
Biological Process GO:1905906 regulation of amyloid fibril formation
Biological Process GO:1905908 positive regulation of amyloid fibril formation
Biological Process GO:1905945 regulation of response to calcium ion
Biological Process GO:1990000 amyloid fibril formation
Biological Process GO:1990535 neuron projection maintenance
Biological Process GO:2000406 positive regulation of T cell migration
Biological Process GO:2000463 positive regulation of excitatory postsynaptic potential
Cellular Component GO:0005576 extracellular region
Cellular Component GO:0005615 extracellular space
Cellular Component GO:0005623 cell
Cellular Component GO:0005634 nucleus
Cellular Component GO:0005641 nuclear envelope lumen
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0005764 lysosome
Cellular Component GO:0005768 endosome
Cellular Component GO:0005769 early endosome
Cellular Component GO:0005791 rough endoplasmic reticulum
Cellular Component GO:0005794 Golgi apparatus
Cellular Component GO:0005798 Golgi-associated vesicle
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0005905 clathrin-coated pit
Cellular Component GO:0005911 cell-cell junction
Cellular Component GO:0008021 synaptic vesicle
Cellular Component GO:0009986 cell surface
Cellular Component GO:0016020 membrane
Cellular Component GO:0016021 integral component of membrane
Cellular Component GO:0030134 COPII-coated ER to Golgi transport vesicle
Cellular Component GO:0030424 axon
Cellular Component GO:0030426 growth cone
Cellular Component GO:0031410 cytoplasmic vesicle
Cellular Component GO:0031594 neuromuscular junction
Cellular Component GO:0032991 protein-containing complex
Cellular Component GO:0034361 very-low-density lipoprotein particle
Cellular Component GO:0034362 low-density lipoprotein particle
Cellular Component GO:0034363 intermediate-density lipoprotein particle
Cellular Component GO:0034364 high-density lipoprotein particle
Cellular Component GO:0035253 ciliary rootlet
Cellular Component GO:0042995 cell projection
Cellular Component GO:0043005 neuron projection
Cellular Component GO:0043235 receptor complex
Cellular Component GO:0044297 cell body
Cellular Component GO:0044304 main axon
Cellular Component GO:0045121 membrane raft
Cellular Component GO:0045177 apical part of cell
Cellular Component GO:0048471 perinuclear region of cytoplasm
Cellular Component GO:0048786 presynaptic active zone
Cellular Component GO:0051233 spindle midzone
Cellular Component GO:0055037 recycling endosome
Cellular Component GO:0070381 endosome to plasma membrane transport vesicle
Cellular Component GO:0097449 astrocyte projection
Cellular Component GO:0098793 presynapse
Cellular Component GO:0098794 postsynapse
Cellular Component GO:0106003 amyloid-beta complex
Cellular Component GO:1990761 growth cone lamellipodium
Cellular Component GO:1990777 lipoprotein particle
Cellular Component GO:1990812 growth cone filopodium
Molecular Function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
Molecular Function GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding
Molecular Function GO:0001664 G protein-coupled receptor binding
Molecular Function GO:0004867 serine-type endopeptidase inhibitor activity
Molecular Function GO:0005102 signaling receptor binding
Molecular Function GO:0005109 frizzled binding
Molecular Function GO:0005158 insulin receptor binding
Molecular Function GO:0005178 integrin binding
Molecular Function GO:0005515 protein binding
Molecular Function GO:0008201 heparin binding
Molecular Function GO:0016504 peptidase activator activity
Molecular Function GO:0019899 enzyme binding
Molecular Function GO:0030414 peptidase inhibitor activity
Molecular Function GO:0030546 signaling receptor activator activity
Molecular Function GO:0033130 acetylcholine receptor binding
Molecular Function GO:0034185 apolipoprotein binding
Molecular Function GO:0042056 chemoattractant activity
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0042803 protein homodimerization activity
Molecular Function GO:0043395 heparan sulfate proteoglycan binding
Molecular Function GO:0046872 metal ion binding
Molecular Function GO:0046875 ephrin receptor binding
Molecular Function GO:0046914 transition metal ion binding
Molecular Function GO:0046982 protein heterodimerization activity
Molecular Function GO:0046983 protein dimerization activity
Molecular Function GO:0050750 low-density lipoprotein particle receptor binding
Molecular Function GO:0050786 RAGE receptor binding
Molecular Function GO:0051087 chaperone binding
Molecular Function GO:0051425 PTB domain binding
Molecular Function GO:0070851 growth factor receptor binding

Gene - GO associations are updated daily from MGI


The KOMP Repository Collection is located at the MMRRC at the University of California, Davis and Children’s Hospital Oakland Research Institute. Question? Comments? For Mice, Cells, and germplasm please contact us at mmrrc@ucdavis.edu, US 1-888-KOMP-MICE or International +1-530-752-KOMP, or for vectors komporders@chori.org or +1-510-450-7917.