Beginning January 1, 2012, the Knockout Mouse Project (KOMP) Repository is now fully self-supporting. Therefore, costs to distribute products (vectors, ES cells, mice, germplasm) and offer services (microinjection, cryopreservation and recovery, germline transmission testing, genotyping, etc.) will no longer be subsidized by the NIH. As a result, our fee structure will be changing February 1, 2012. The new fee structure will allow for more flexibility in ordering fully verified ES cells products.

Submit your KOMP mutant mice back to us--bolster the global scientific community, fulfill your NIH sharing obligation, and get a refund! Visit the KOMP Sharing Plan page for more information.

September 29, 2011 - $34 million grant to create mouse models of human diseases awarded to U.C. Davis and others. Read More

Around 80 KOMP genes have recently been made available as live mice! Order soon as these lines will enter the cryoarchiving process on October 15th. View the list and place your order.

September 20, 2011 - NHGRI has developed its first education ‘App’! If you use an iPhone, iPad, or iPod Touch, you can now have free access to the popular NHGRI Talking Glossary of Genetics anywhere you go. In addition to offering easy-to-understand written definitions, users can listen to an NHGRI scientist explain each term and provide contextual learning tips. The glossary App contains nearly 200 color illustrations and more than thirty 3-D animations that illustrate genetic concepts. The mobile version of the glossary includes all of the bells and whistles of the online version, including new and simplified search methods, easy-to-find terms of interest, alphabetical navigation to search functions, and lists of related terms. There's even a "Test Your Gene Knowledge" quiz, so users can check their understanding of the glossary's contents. The majority of the glossary terms are studied in middle school, high school, and collegiate science classes. Teachers at all levels were used to help compile the terms and evaluate the glossary during development. It’s free and it’s fun. Either go to the iTunes App Store and search “talking glossary” or click on the App Store link below. Link to App Store

August 17, 2011 - August 17, 2011.  A commentary by Gregory Farber and Linda Weiss entitled 'Core Facilities: Maximizing the Return on Investment, appears in this week's online version of Science Translational Medicine (Volume 3, Issue 95, page 95, August 10, 2011) at http://stm.sciencemag.org/content/3/95/95cm21.abstract .  From the posted abstract..."To conduct high-quality state-of-the-art research, clinical and translational scientists need access to specialized core facilities and appropriately trained staff. In this time of economic constraints and increasing research costs, organized and efficient core facilities are essential for researchers who seek to investigate complex translational research questions. Here, we describe efforts at the U.S. National Institutes of Health and academic medical centers to enhance the utility of cores.".

July 5, 2011 - The Mouse Biology Program presented the following posters and platform presentation at the Mouse Genetics 2011 meeting in Washington D.C.

K312
Repository
Transcriptome
LacZ
Silencing
KOMPCluster
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The Mouse Genetics 2011 meeting is in progress right now at Washington D.C. The KOMP Repository and Mouse Biology Program invites you to visit our booth(#206), discover the products/services we have to offer and grab some free souvenirs!
More Information

Genetic Manipulation of ES Cells
31 October - 13 November 2011
Wellcome Trust Genome Campus, Hinxton, Cambridge
Deadline for applications: 8 July 2011.
Wellcome Trust Advanced Courses

Mouse Molecular Genetics
20-23 September 2011

For the past 24 years, the Mouse Molecular Genetics meeting has been a leading forum for researchers who apply the methods of genetics and genomics to fundamental problems in mammalian biology, including from stem cell biology, early development, and models of human disease. In particular, the meeting showcases the latest technical developments in genetics and engineering of the mouse genome, and this year will feature a session devoted to imaging. The Mouse Molecular Genetics meeting assembles leaders in the field to present unpublished research findings, encourages junior investigators to participate in oral and poster presentations, and provides a stimulating environment for the exchange of ideas and information.
Registration / More information

Submit your KOMP mutant mice back to us--bolster the global scientific community, fulfill your NIH sharing obligation, and earn cash! Visit the KOMP Sharing Plan page for more information.

March 24, 2011 - The NIH Common Fund (http://commonfund.nih.gov) was enacted into law by Congress through the 2006 NIH Reform Act to support cross-cutting, trans-NIH programs that require participation by at least two NIH Institutes or Centers (ICs) or would otherwise benefit from strategic planning and coordination. The NIH Common fund provides support to the KOMP2 Phenotyping Program, which will provide new tools and methods, a comprehensive mutant mosue databse and library, and conduct broad, standardized, and high-throughput analysis of mutant mouse models produced by the International Knockout Mouse Consortium. Learn more about KOMP2 Phenotyping and the NIH Common Fund here: http://commonfund.nih.gov/KOMP2/.

The KOMP Repository would like to extend support to the residents of Japan following the extremely large earthquake and resulting tsunami that has left millions of people without electricity or water.

Please consider donating funds to the American Red Cross to hasten relief to those impacted by the tragedy.

To our customers in Japan, we hope you are well and safe. We will be doing our best to check in to discuss any obstacles these events may present while fulfilling your orders. If you have any questions or concerns please contact us (service@komp.org or +1-530-752-5667).

The KOMP website is available for easy access on mobile phones! Visit m.komp.org to check your orders and favorite genes on the go.

Submit your KOMP mutant mice back to us--bolster the global scientific community, fulfill your NIH sharing obligation, and earn cash! Visit the KOMP Sharing Plan page for more information. KOMP Sharing Plan

January 21, 2011 - The 10th Transgenic Technology Meeting (TT2011) web site has just been launched. Registration and Abstract Submission are now OPEN. Go to http://www.tt2011.org. The TT2011 meeting, organized by the International Society for Transgenic Technologies (ISTT) will be held at the TradeWinds Island Grand Resort, in St Pete Beach, Florida, USA, on October 24-26, 2011. http://www.tt2011.org

December 13, 2010 - NIH is poised to create a new translational and therapeutics institute. Read more at nature.com

December 10, 2010 - Dr. Lluis Montoliu, president of the International Society for Transgenic Technologies (ISTT), announced today that Prof. Ralph L. Brinster, Richard King Mellon Professor of Reproductive Physiology at the University of Pennsylvania, will be awarded the 8th ISTT Prize for his outstanding contributions to the field of transgenic technologies. Dr. Montoliu writes, that Dr. Brinster's "exceptional, fruitful and highly stimulating contributions to the field of animal transgenesis are recognised with this award. Very few scientists have contributed as much to the field of modern animal biotechnology as Dr. Brinster did in his pioneering work in establishing, developing and advancing animal transgenesis methods and principles. This seminal work in mouse transgenesis, often done in collaboration with Richard Palmiter, laid the foundations for the field and greatly advanced our understanding of the mechanisms of gene regulation." The award will be presented to Dr. Brinster at the next international meeting of the ISTT, in TradeWinds Island Resort, St Pete Beach, Florida, USA, on October 24-26, 2011. Dr. Brinster will present the keynote address at the meeting and will be given lifetime honorary membership in the ISTT and a sterling silver sculpture of a mouse blastocyst created by the Hungarian artist Mr. Bela Rozsnyay. The ISTT Prize is generously sponsored by genOway. Additional information can be found at www.transtechsociety.org/blog

Welcome to the redesigned KOMP Repository website. We hope the new layout will help you easily make use of all of our resources, but if you experience any problems or can't find something you're looking for, be sure to email us at service@komp.org.

Important notice to KOMP2 Production Center Applicants. Click here for more details

International Gene Trap Consortium website now hosted by the Mouse Biology Program. Read more about the IGTC move at the MBP blog..

International Gene Trap Consortium website now hosted by the Mouse Biology Program. Read more about the IGTC move at the MBP blog..

October 4, 2010 - The Nobel Prize in Physiology or Medicine 2010 is awarded to Robert G. Edwards "for the development of in vitro fertilization", a technique used extensively in the animal world, especially for the rapid generation and production of genetically-altered mouse strains. . http://nobelprize.org/

September 13, 2010 - Survey on Cre-LoxP System Tools

CREATE is an international Coordination Action addressing a large scale data gathering activity for systematic conditional mouse mutagenesis. As part of the CREATE mandate, we want to determine the tools you need. Therefore we invite you to participate in an on-line survey at our new website, www.creline.org. Your responses to this survey will help us to identify tissues, cell lineages and biological fields for which there are insufficient or ineffective Cre drivers. These will form the basis for selection of >250 new Cre driver mouse lines that will be generated by the EU consortium EUCOMMTOOLS to be distributed worldwide through the European Mutant Mouse Archive (EMMA) and by the Canadian NorCOMM2ls Project to be distributed by the Canadian Mouse Mutant Repository (CMMR).

The results of the survey as well as production status of the new Cre lines will be available at CREATE website. www.creline.org

August 20, 2010 - The NIH roadmap announces the next phase of the Knockout Mouse Program. More information

July 19, 2010 - The KOMP Repository is featured in the Summer 2010 NCRR Reporter! Better Mouse Models to Conquer Disease

July 29, 2010 - NIH Receives Donation of Knockout Mice Collection Used To Study Secreted and Transmembrane Proteins. Read the article at genome.gov

Tang et al.: A mouse knockout library for secreted and transmembrane proteins. Nature Biotechnology (2010) doi:10.1038/nbt.1644.

: Mouse megascience. Nature 465, 526 (03 June 2010).

May 20, 2010 - Genetics: Synthetic Biology Breakthrough. In the most recent edition of ScienceExpress, Gibson et al. report the creation of a bacterial cell controlled by a chemically synthesized genome. A related News story by E. Pennisi highlights the new work, which involved stepwise creation of a bacterial chromosome and the transfer of it into a related bacterium, where it replaced the native DNA. Read more at ScienceExpress

Wellcome Trust Advance Course: Genetic Manipulation of ES Cells. (15-28 November 2010).
Find out more!

March 10, 2010 - NIH Director Receives Albany Medical Center Prize: Francis S. Collins, M.D., Ph.D. has been named a recipient for his leading role in mapping the human genome. Read the news release

Pathobiology of the Mouse, Part B is now open for enrollment. UC Davis Extension. UC Davis Extension

November 18, 2009 - Nature editorial: Information-sharing resources are essential to biologists and deserve international support. Read editorial at Nature.org

Introducing Gene Cloud (www.genecloud.org)! Gene Cloud is a graphical tool for the exploration of relatedness amongst genes.
You can use Gene Cloud by visiting the link and searching for your favorite gene, or by finding your gene on this site and clicking the Gene Cloud link. Check it out!

KOMP needs your input! Please read about our phenotyping survey on our blog and get involved to have your voice heard.

September 21, 2009 - Knockout mouse research saves lives! Watch the 60 second clip, Larry's Story on YouTube. Read more at researchsaves.org

October 6, 2009 - NIH Grantees Win 2009 Nobel Prize in Physiology or Medicine for Telomere Research. Click here to read the release.

October 5, 2009 - NYT brings Collins to the people. Read the article at NYT

Milestone Reached: The KOMP Repository membership reached 2,500 registered users.

Anastassiadis K, Fu J, Patsch C, Hu S, Weidlich S, Duerschke K, Buchholz F, Edenhofer F, Stewart AF.: Dre recombinase, like Cre, is a highly efficient site-specific recombinase in E. coli, mammalian cells and mice. Dis. Model. Mech. August 19, 2009, doi: 10.1242/dmm.003087 .

August 18, 2009 - Collins sets out his vision for the NIH. Read the article at Nature

August 18, 2009 - The Check-Up. Read the article at Nature

New Service: Search for KOMP products with your name or your favorite PubMed keywords on our Reference Search page. We also sped up our Gene Ontology Search and improved on our other Advanced Search functions.

Mouse Genetics & Genomics: Development & Disease Conference hosted by Cold Spring Harbor Laboratory and the Wellcome Trust Conference Centre at the Wellcome Trust Genome Campus located in Hinxton, Cambridge, UK. Conference begins on Wednesday, September 2nd, 2009 at 3 p.m. and concludes on Sunday, September 6 after lunch. The specific goal of the conference is to bring together a diverse group of scientists studying various molecular and genetic aspects of mammalian development. The meeting is intended to provide a format for the exchange of ideas and information, to discuss the latest research findings and technical advances towards the study of mammalian development and disease. Abstract deadline: July 1, 2009. Organized by Kathryn Anderson, Haruhiko Koseki, Michael Shen and William Skarnes. .
Register online

Pettitt et al.: Agouti C57BL/6N embryonic stem cells for mouse genetic resources. Nature Methods, 2009.

June 15, 2009 - The Center for Genomic Pathology (CGP) is a not-for-profit educational foundation whose goal is to collect, integrate and disseminate knowledge about Genomic Pathology. The CGP is designed to support educational activities of the Academy of Genomic Pathology (AGP). CGP will provide training and expertise in comparative pathology with an emphasis on the pathobiology of the genetically manipulated laboratory mouse as applied to human disease. Our objective is to train the next generation of comparative pathologists their students and staff helping them meet the needs of the scientific community with accurate interpretation of the diseases produced in mice through experimental and genetic manipulation. This objective is being realized using remote and on-site training based on our annotated, digitized images and databases coupled with modern telepathology and Distance Learning systems. A network of international expert comparative mouse pathologists (AGP) provides interactive training and consultation. The Center for Genomic Pathology

June 11, 2009 - Nature editorial pleas, "Journals and funders must insist that genetically modified mouse strains are fully available.". The Sharing Principle (Nature Vol 459, June 2009)

October 26 – November 8, 2009: Advanced Course on Genetic Manipulation of ES Cells at the Wellcome Trust Sanger Institute.
Course Information

May 28, 2009 - The genetically-altered mouse continues to prove its leading role as a human surrogate in biomedical research that reveals underlying pathophysiological causes and consequences of disease. Church et al's recently published article in PloS Biology (May 2009, Volume 7, Issue 5) describes painstaking work to refine the genetic code for the mouse, reinforcing its value as an animal model. Build 36 uncovers sequence information specific to previously unknown mouse genes, many of which have orthologs in humans. We now have the most refined, legible, and complete genetic sequence of the mouse, with which we can conduct key "knockout" and other genetic manipulations in the mouse in order to develop more and better models of human disease, development, and behavior.

New Service: You can find KOMP products using your microarray results by pasting the list of differentially regulated Affymetrix oligoset IDs (mouse or human) into our advanced search window KOMP Microarray Search.
Gene Expression Records (GXD) are linked from the Gene Information Pages.

Membership milestone: The www.KOMP.org website reached 2,000 registered users. All registered users can use the blog feature to discuss their projects and ask the KO community project-related questions. KOMP blog

April 28, 2009 - WASHINGTON -- The National Academy of Sciences today announced the election of 72 new members and 18 foreign associates from 15 countries in recognition of their distinguished and continuing achievements in original research. This list includes Professor Glauco P Tocchini-Valentini, Director of the Istituto di Biologia Cellulare, National Research Council of Italy, Monterotondo Scalo (Italy), and Dr. Neal G. Copeland, Executive Director, Institute of Molecular and Cell Biology, Proteos, Singapore. Professor Tocchini-Valentini is one of Europe's leading experts in cell biology and studies genetic regulation of cell function, notably the intricate and complex role of RNA. He is also a great innovator in the field of mouse biology, contributing novel ways to consider how to most effectively phenotype genetically altered mice. Dr. Copeland is himself an expert in the field of mouse genetics and cancer, and for the last several years has served as the Chairman of the Panel of Scientific Academy. Additional information about the Academy and its members is available online at

New Video Tutorials available on how to set up an account and how to place an order. Click here to see the tutorials

New Service Available: If you have made mice from KOMP ES cells, you can send them to the Repository for archiving, safekeeping, and distribution. Contact us at service@komp.org for further information.

To nominate your genes for development start by searching for them in our database, then use the nominate link on the right hand side of the table.

The KOMP website will now allow you to search the MMRRC catalog. Simply start searching as you would normally, then click on the 'MMRRC Search' link at the bottom of the page.

Schnabel: (News Feature) Neuroscience: Standard model. Nature; 2008; 454:682.

Dance: Mouse miRNA library to open: Biologists launch knockout resource. Nature; 2008; 454:264.

Cardiff et al: Perspective: 'One medicine—one pathology': are veterinary and human pathology prepared? Lab. Investigation; 2008; 88:18.

Cardiff: Correspondence: Pathologists needed to cope with mutant mice. Nature 2007; 447:528.

Editorial: Mutant mice galore. Nature 2007. 446:469.

The International Mouse Knockout Consortium: A mouse for all reasons. Cell (2007) 128:9-13.

Pollock et al.: An update on the Knockout Mouse Project and EUCOMM Insertional Mutagenesis Project . Am.J.Med.Gen. Part B. Neuropsychiatric Gen. 2006. 141B(7):686.

Pollock: The NIH knockout mouse project (KOMP). Am.J.Med.Gen Part B. Neuropsychiatric Gen. 2006. 141B(7):686.

Accili: A note of caution on the Knockout Mouse Project. Nat.Gen. 2004. 36(11):1132.

Austin et al.: The Knockout Mouse Project. Nat.Gen. 2004. 36(9):921.

July 27, 2007 - NIH Awards Nearly $5 Million to Fund Knockout Mouse Repository. (Read more...)

March 12, 2007 - Administrative Supplement for Making Knockout Mice. (Read more...)

January 12, 2007 - Request for community input for the nomination and prioritization of genes to be targeted in the KOMP. (Read more...)

September 1, 2006 - NIH KOMP mutagenesis program awarded to UC Davis . (Read more...)

September 7, 2006 - NIH Launches Knockout Mouse Project. (Read more...)

June 12, 2007 - NIH Launches Effort to Place More Knockout Mice in Public Repositories. (Read more...)

2007 Noble price in medicine or physiology goes to pioneers in gene targeting in mice. Watch the video.

Learn how the Nobel Committee decided on the 2007 awar in medicine or physiology. Watch the video.