The KOMP website is now available for easy access on mobile phones! Visit m.komp.org to check the status of your orders and favorite genes on the go.

Also announcing the KOMP Sharing Plan! Submit your KOMP mutant mice back to us--bolster the global scientific community, fulfill your NIH sharing obligation, and earn cash! Visit the KOMP Sharing Plan page for more information. KOMP Sharing Plan

Pathobiology of the Mouse, Part B is now open for enrollment. UC Davis Extension. UC Davis Extension

November 18, 2009 - Nature editorial: Information-sharing resources are essential to biologists and deserve international support. Read editorial at Nature.org

Introducing Gene Cloud (www.genecloud.org)! Gene Cloud is a graphical tool for the exploration of relatedness amongst genes.
You can use Gene Cloud by visiting the link and searching for your favorite gene, or by finding your gene on this site and clicking the Gene Cloud link. Check it out!

KOMP needs your input! Please read about our phenotyping survey on our blog and get involved to have your voice heard.

September 21, 2009 - Knockout mouse research saves lives! Watch the 60 second clip, Larry's Story on YouTube. Read more at researchsaves.org

October 6, 2009 - NIH Grantees Win 2009 Nobel Prize in Physiology or Medicine for Telomere Research. Click here to read the release.

October 5, 2009 - NYT brings Collins to the people. Read the article at NYT

Milestone Reached: The KOMP Repository membership reached 2,500 registered users.

Anastassiadis K, Fu J, Patsch C, Hu S, Weidlich S, Duerschke K, Buchholz F, Edenhofer F, Stewart AF.: Dre recombinase, like Cre, is a highly efficient site-specific recombinase in E. coli, mammalian cells and mice. Dis. Model. Mech. August 19, 2009, doi: 10.1242/dmm.003087 .

August 18, 2009 - Collins sets out his vision for the NIH. Read the article at Nature

August 18, 2009 - The Check-Up. Read the article at Nature

New Service: Search for KOMP products with your name or your favorite PubMed keywords on our Reference Search page. We also sped up our Gene Ontology Search and improved on our other Advanced Search functions.

Mouse Genetics & Genomics: Development & Disease Conference hosted by Cold Spring Harbor Laboratory and the Wellcome Trust Conference Centre at the Wellcome Trust Genome Campus located in Hinxton, Cambridge, UK. Conference begins on Wednesday, September 2nd, 2009 at 3 p.m. and concludes on Sunday, September 6 after lunch. The specific goal of the conference is to bring together a diverse group of scientists studying various molecular and genetic aspects of mammalian development. The meeting is intended to provide a format for the exchange of ideas and information, to discuss the latest research findings and technical advances towards the study of mammalian development and disease. Abstract deadline: July 1, 2009. Organized by Kathryn Anderson, Haruhiko Koseki, Michael Shen and William Skarnes. .
Register online

Pettitt et al.: Agouti C57BL/6N embryonic stem cells for mouse genetic resources. Nature Methods, 2009.

June 15, 2009 - The Center for Genomic Pathology (CGP) is a not-for-profit educational foundation whose goal is to collect, integrate and disseminate knowledge about Genomic Pathology. The CGP is designed to support educational activities of the Academy of Genomic Pathology (AGP). CGP will provide training and expertise in comparative pathology with an emphasis on the pathobiology of the genetically manipulated laboratory mouse as applied to human disease. Our objective is to train the next generation of comparative pathologists their students and staff helping them meet the needs of the scientific community with accurate interpretation of the diseases produced in mice through experimental and genetic manipulation. This objective is being realized using remote and on-site training based on our annotated, digitized images and databases coupled with modern telepathology and Distance Learning systems. A network of international expert comparative mouse pathologists (AGP) provides interactive training and consultation. The Center for Genomic Pathology

June 11, 2009 - Nature editorial pleas, "Journals and funders must insist that genetically modified mouse strains are fully available.". The Sharing Principle (Nature Vol 459, June 2009)

October 26 – November 8, 2009: Advanced Course on Genetic Manipulation of ES Cells at the Wellcome Trust Sanger Institute.
Course Information

May 28, 2009 - The genetically-altered mouse continues to prove its leading role as a human surrogate in biomedical research that reveals underlying pathophysiological causes and consequences of disease. Church et al's recently published article in PloS Biology (May 2009, Volume 7, Issue 5) describes painstaking work to refine the genetic code for the mouse, reinforcing its value as an animal model. Build 36 uncovers sequence information specific to previously unknown mouse genes, many of which have orthologs in humans. We now have the most refined, legible, and complete genetic sequence of the mouse, with which we can conduct key "knockout" and other genetic manipulations in the mouse in order to develop more and better models of human disease, development, and behavior.

New Service: You can find KOMP products using your microarray results by pasting the list of differentially regulated Affymetrix oligoset IDs (mouse or human) into our advanced search window KOMP Microarray Search.
Gene Expression Records (GXD) are linked from the Gene Information Pages.

Membership milestone: The www.KOMP.org website reached 2,000 registered users. All registered users can use the blog feature to discuss their projects and ask the KO community project-related questions. KOMP blog

April 28, 2009 - WASHINGTON -- The National Academy of Sciences today announced the election of 72 new members and 18 foreign associates from 15 countries in recognition of their distinguished and continuing achievements in original research. This list includes Professor Glauco P Tocchini-Valentini, Director of the Istituto di Biologia Cellulare, National Research Council of Italy, Monterotondo Scalo (Italy), and Dr. Neal G. Copeland, Executive Director, Institute of Molecular and Cell Biology, Proteos, Singapore. Professor Tocchini-Valentini is one of Europe's leading experts in cell biology and studies genetic regulation of cell function, notably the intricate and complex role of RNA. He is also a great innovator in the field of mouse biology, contributing novel ways to consider how to most effectively phenotype genetically altered mice. Dr. Copeland is himself an expert in the field of mouse genetics and cancer, and for the last several years has served as the Chairman of the Panel of Scientific Academy. Additional information about the Academy and its members is available online at

New Video Tutorials available on how to set up an account and how to place an order. Click here to see the tutorials

New Service Available: If you have made mice from KOMP ES cells, you can send them to the Repository for archiving, safekeeping, and distribution. Contact us at service@komp.org for further information.

To nominate your genes for development start by searching for them in our database, then use the nominate link on the right hand side of the table.

The KOMP website will now allow you to search the MMRRC catalog. Simply start searching as you would normally, then click on the 'MMRRC Search' link at the bottom of the page.

Schnabel: (News Feature) Neuroscience: Standard model. Nature; 2008; 454:682.

Dance: Mouse miRNA library to open: Biologists launch knockout resource. Nature; 2008; 454:264.

Cardiff et al: Perspective: 'One medicine—one pathology': are veterinary and human pathology prepared? Lab. Investigation; 2008; 88:18.

Cardiff: Correspondence: Pathologists needed to cope with mutant mice. Nature 2007; 447:528.

Editorial: Mutant mice galore. Nature 2007. 446:469.

The International Mouse Knockout Consortium: A mouse for all reasons. Cell (2007) 128:9-13.

Pollock et al.: An update on the Knockout Mouse Project and EUCOMM Insertional Mutagenesis Project . Am.J.Med.Gen. Part B. Neuropsychiatric Gen. 2006. 141B(7):686.

Pollock: The NIH knockout mouse project (KOMP). Am.J.Med.Gen Part B. Neuropsychiatric Gen. 2006. 141B(7):686.

Accili: A note of caution on the Knockout Mouse Project. Nat.Gen. 2004. 36(11):1132.

Austin et al.: The Knockout Mouse Project. Nat.Gen. 2004. 36(9):921.

July 27, 2007 - NIH Awards Nearly $5 Million to Fund Knockout Mouse Repository. (Read more...)

March 12, 2007 - Administrative Supplement for Making Knockout Mice. (Read more...)

January 12, 2007 - Request for community input for the nomination and prioritization of genes to be targeted in the KOMP. (Read more...)

September 1, 2006 - NIH KOMP mutagenesis program awarded to UC Davis . (Read more...)

September 7, 2006 - NIH Launches Knockout Mouse Project. (Read more...)

June 12, 2007 - NIH Launches Effort to Place More Knockout Mice in Public Repositories. (Read more...)

2007 Noble price in medicine or physiology goes to pioneers in gene targeting in mice. Watch the video.

Learn how the Nobel Committee decided on the 2007 awar in medicine or physiology. Watch the video.