About KOMP312
The NHGRI and NCRR have recently funded the KOMP Mutagenesis Project and the KOMP Repository to create and characterize 312 unique mutant lines from targeted ESCs developed by the CHORI-Sanger-UC Davis and Regeneron consortium. This mouse production and phenotyping effort, led by Kent Lloyd, D.V.M., Ph.D. at UC Davis, and Pieter de Jong, Ph.D with David West, Ph.D. at Children’s Hospital of Oakland Research Institute (CHORI) will contribute a significant number of live mutants, along with phenotype data, to the scientific community in order to stimulate additional research with these reagents. The phenotype screen includes fertility and viability and LacZ reporter gene tissue distribution in 312 mutant lines; and necropsy, behavioral phenotypes and a comprehensive analysis of compensatory tanscriptome changes in -/- mice in multiple tissues for 100 of these mutants. The tissue pattern of LacZ expression will inform those tissues selected for more detailed analyses of gene expression. Mice created for this project will be available under the standard terms and conditions for live and cryopreserved mutants from the KOMP Repository as soon as they are produced. And the phenotype data will be made available through a web portal at the KOMP website. We are currently selecting genes for mutant production and you will soon be able to NOMINATE YOUR GENE here!
The NHGRI and NCRR have recently funded the KOMP Mutagenesis Project and the KOMP Repository to create and characterize 312 unique mutant lines from targeted ESCs developed by the CHORI-Sanger-UC Davis and Regeneron consortium. This mouse production and phenotyping effort, led by Kent Lloyd, D.V.M., Ph.D. at UC Davis, and Pieter de Jong, Ph.D with David West, Ph.D. at Children’s Hospital of Oakland Research Institute (CHORI) will contribute a significant number of live mutants, along with phenotype data, to the scientific community in order to stimulate additional research with these reagents. The phenotype screen includes fertility and viability and LacZ reporter gene tissue distribution in 312 mutant lines; and necropsy, behavioral phenotypes and a comprehensive analysis of compensatory tanscriptome changes in -/- mice in multiple tissues for 100 of these mutants. The tissue pattern of LacZ expression will inform those tissues selected for more detailed analyses of gene expression. Mice created for this project will be available under the standard terms and conditions for live and cryopreserved mutants from the KOMP Repository as soon as they are produced. And the phenotype data will be made available through a web portal at the KOMP website. We are currently selecting genes for mutant production and you will soon be able to NOMINATE YOUR GENE here!
| Tuesday, March 9th 2010 06:36:22 PM | |