Fees for KOMP Products and Services

The KOMP Repository was originally funded by a U42 grant from the National Institutes of Health (NIH)/National Center for Research Resources (NCRR) with a subcontract to Children's Hospital Oakland Research Institute. While our NIH grant enabled us to establish the repository infrastructure, this grant has now ended and fees have been modified for KOMP products and services to cover our operating costs.

The repository distributes KOMP vectors, ES cells, mice, and other materials, such as cryopreserved germplasm, DNA, etc. In addition, the repository also offers services to enhance the utility of these products, including ES cell microinjection, recombination, genetic analysis, pathogen screening, cryo-recovery, colony management, and other services.

The prices for KOMP products and services are shown below:

How to place an order

When you are ready to place your request, you can do so online at www.komp.org. You can read an overview of the ordering process. For additional services and package rates please contact us at service@komp.org or 1-888-KOMP-MICE.

Payment

For domestic (within the USA) requests we accept payment via Purchase Order, Pre-Paid Check, Wire Transfer, and Credit Card. For international requests (outside the USA) we do require pre-payment via Wire Transfer, Pre-Paid Check, or Credit Card. Orders will not begin processing until payment or payment details have been received. Pro-forma invoices can be provided upon request. Please, do not send payment or payment details until you have placed your order online and have received an estimate from our distribution representative.

Courier and shipping fees

Shipping and handling fees are not included in the above estimates. Handling fees will be included in your order estimate when the order is placed. In general, domestic shipments (U.S., not including Alaska, Hawaii, or insular territories) are subject to a $48 handling fee per shipment, plus mouse crate ($29 per 2-compartment crate) or cell packaging ($9) fees; all international shipments (plus Alaska, Hawaii and insular territories) are subject to handling fees of $96 up to $144, per shipment, plus crate or package fees, depending on export documentation requirements for the receiving country. Special packaging requirements will incur extra fees. (Note: Mexico and Canada are international shipments requiring customs documentation.)

For most ES cell and vector shipments we can use Federal Express, and request that you provide us with your account number. There are some exceptions for certain countries that require extra documentation and handling, and for these we will recommend another courier.

For cryo-materials, we can use Federal Express for domestic shipments, but for most international shipments we use one of our preferred international couriers, such as World Courier, BioCair or TransporTech LLC, as customs requirements for biological materials are usually very strict.

For live animal shipments, we use one of our preferred live animal couriers, such as World Courier and TransporTech LLC. We prefer that you provide a courier account number so shipping fees will be billed directly to your institution from the courier.

If you have a preferred courier, please let us know, as we will try to work with you on using that courier. However there may be instances in which we strongly recommend against certain couriers for specific products based on our extensive experience in shipping mice and biologic materials.

Notes

*A Fully Verified ES cell clone includes development of genotyping protocols, genetic verification at the 3' and 5' ends, vector copy number = 1, presence or loss of Y chromosome, chromosome count > or = 50% euploid, and mycoplasma and MPV tested. Type of genetic testing varies for CSD and Velocigene targets. Approximately 30% of KOMP clones tested fail genetic analysis and will require a new clone be selected for expansion and testing. Due to the average germline rate for KOMP targets, we recommend requesting and injecting 2 - 3 clones per targeted allele.

**Basic Microinjection provides one day of injection services, including production of 28-32 injected blastocysts, transfer to 2 pseudopregnant embryo recipients, and derivation of litters containing a minimum of 8 total pups. There are no guarantees for derivation of high percent chimeric mice with basic microinjection services.

***Guaranteed Microinjection Services includes microinjection of multiple ES cell clones per target (when available, ordered, and passing QC), and we guarantee to produce at least 2 male chimeras that are greater than 50% ES cell derived (based on coat color assessment), or your money back. The customer will not receive any ES cells as part of this package, but additional vials of cells can be ordered.

**** This is an estimated fee for Germline Transmission Testing, which includes Project Management and monthly updates for mating up to three of the highest percent male chimeras for a maximum of 120 days, per diem of breeder and non-breeder mice, colony husbandry, C57BL/6N female purchase, and genotyping of litters; the actual fees depend on how well the mice breed, and number of litters generated and tested before heterozygous mice are identified, and fees may be higher or lower than estimated here. If 3 chimeras are not available we will rotate additional female(s) with the available chimera. If breeding is requested beyond 120 days additional fees will be billed. This is not a guaranteed service; fees are billed on services provided, including per diem, genotyping, project and colony management. Average germline success rates for the KOMP Project can be found at https://www.komp.org/gltrates.php

***** One aliquot is one vial or straw of sperm with sufficient concentration to fertilize multiple clutches of oocytes, for derivation of at least one litter of mice if performed at the KOMP Repository.